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Transcranial direct stimulation and fluoxetine for the treatment of depression

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Check out this Knowledge Base article from StressTherapy Solutions: Transcranial direct stimulation and fluoxetine for the treatment of depression.

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Study at a glance

Area
Depression & Mood
Study type
Controlled study
Authors
Rigonatti SP, Boggio PS, Myczkowski ML, Otta E, Fiquer JT, Ribeiro RB, et al.
Journal
European Psychiatry
Year
2008
Participants
42 (21 + 11 + 10)
Population
Adults
Protocol
Anodal tDCS, left DLPFC, vs fluoxetine 20 mg
Sessions
10 tDCS sessions

Key findings

  • tDCS matched fluoxetine at six weeks
  • Faster early improvement with tDCS

DOI 10.1016/j.eurpsy.2007.09.006 → PubMed 18023968 →

Results from a sham-controlled tDCS trial in major depression were compared with an open-label group of similar patients given fluoxetine 20 mg a day. After six weeks, tDCS and fluoxetine reduced depression by similar amounts, but tDCS worked faster: a 43% reduction after two weeks against 15% for fluoxetine.