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Combined LORETA and fMRI study of recognition of eyes and eye movement in schizophrenia

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Check out this Knowledge Base article from StressTherapy Solutions: Combined LORETA and fMRI study of recognition of eyes and eye movement in schizophrenia.

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Study at a glance

Area
Other research
Study type
Observational study
Published as
Conference paper
Authors
Suzuki A, Kirino E
Journal
International Congress Series
Year
2004
Participants
10 patients and 10 controls (fMRI); 15 patients and 12 controls (ERP)
Protocol
fMRI and ERP-based LORETA during face and eye viewing

Key findings

  • Controls showed stronger fusiform and superior temporal activation to the static face
  • Patients tended to show greater left amygdala activation to moving eyes
  • LORETA showed greater left insula current density in patients for static and leftward-moving eyes
  • Authors link this feature-first processing to interpersonal deficits in schizophrenia

DOI 10.1016/j.ics.2004.05.043 →

People with schizophrenia and healthy controls viewed a face, eyes alone and moving eyes during fMRI and event-related potential (ERP) recordings, with sources estimated by low resolution brain electromagnetic tomography (LORETA). Controls responded more strongly to the whole face in face-processing regions, while patients showed more activity to eyes in the amygdala and insula. The authors suggest patients may focus on facial details before the whole face, which could relate to their difficulties with social interaction.