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Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP

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Check out this Knowledge Base article from StressTherapy Solutions: Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP.

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Study at a glance

Area
Addiction
Study type
Observational study
Authors
Enoch MA, Shen PH, Ducci F, Yuan Q, Liu J, White KV, Albaugh B, Hodgkinson CA, Goldman D
Journal
PLoS ONE
Year
2008
Participants
328 Plains American Indians, plus a replication sample of 188 Caucasians
Protocol
resting EEG with genome-wide linkage and association analysis

Key findings

  • Alpha, theta and beta power were heritable (0.27-0.58) and stable over 2 years (r = 0.53-0.82)
  • Linkage peaks for all three bands converged on chromosome 5q13-14, with a logarithm of odds (LOD) score of 3.5 for alpha and beta power
  • CRH-BP was associated with alpha power in both the Plains Indian and Caucasian samples
  • The same CRH-BP variants were associated with anxiety disorders in Plains Indians and alcohol use disorders in Caucasians

DOI 10.1371/journal.pone.0003620 → PubMed 18974851 →

A genetic study of the resting EEG as a marker for arousal-related conditions such as anxiety and alcoholism. Researchers ran a whole-genome linkage scan in a large family pedigree of 328 Plains American Indians and checked results in 188 Caucasians. EEG power was heritable and stable over two years, and linkage peaks pointed to the gene for corticotropin releasing hormone-binding protein (CRH-BP), a regulator of the stress response. The authors suggest CRH-BP plays a role in stress-related alcoholism.