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Can EEG‐Neurofeedback Training Enhance Effective Connectivity in People With Chronic Secondary Musculoskeletal Pain? A Secondary Analysis of a Feasibility Randomized Controlled Clinical Trial

STS Instructor Authored by Mark Smith

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Check out this Knowledge Base article from StressTherapy Solutions: Can EEG‐Neurofeedback Training Enhance Effective Connectivity in People With Chronic Secondary Musculoskeletal Pain? A Secondary Analysis of a Feasibility Randomized Controlled Clinical Trial.

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Study at a glance

Area
Pain & Headache
Study type
Randomized controlled trial
Authors
Mathew J, Adhia DB, Smith ML, De Ridder D, Mani R
Journal
Brain and Behavior
Year
2025
Participants
21
Population
Adults, Older adults
Protocol
infraslow neurofeedback (pgACC, dACC, bilateral S1) vs sham
Sessions
9 sessions

Key findings

  • Directed connectivity between pregenual and dorsal anterior cingulate increased with real training
  • Connectivity from pregenual cingulate to somatosensory cortex also increased
  • Flow from right somatosensory cortex to dorsal cingulate decreased
  • Changes were mainly in the infraslow band; larger trials are needed to test clinical benefit

DOI 10.1002/brb3.70541 → PubMed 40437825 →

This secondary analysis used data from a double-blind, sham-controlled feasibility trial in people with painful knee osteoarthritis who had nine sessions of infraslow neurofeedback or sham. The training targeted the pregenual and dorsal anterior cingulate and both primary somatosensory cortices. Using Granger causality to measure the direction of information flow between regions, the real-training group showed stronger connections between the targeted pain-related regions, mostly in the infraslow band.