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The cortical generators of the contingent negative variation in humans: a study with subdural electrodes

STS Instructor Authored by Thomas Collura

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Check out this Knowledge Base article from StressTherapy Solutions: The cortical generators of the contingent negative variation in humans: a study with subdural electrodes.

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Study at a glance

Area
QEEG, Methods & Mechanisms
Study type
Observational study
Authors
Hamano T, Lüders HO, Ikeda A, Collura TF, Comair YG, Shibasaki H
Journal
Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section
Year
1997
Participants
14
Protocol
subdural recording of contingent negative variation and Bereitschaftspotential (Go/NoGo task)

Key findings

  • The early part of the wave arose mainly from prefrontal and supplementary sensorimotor areas
  • The late part involved prefrontal, motor, sensory, temporal, occipital and supplementary areas
  • The scalp-recorded wave appears to be a sum of several cortical sources with different roles
  • The late wave is not the same as the readiness potential and is not purely motor preparation

DOI 10.1016/s0168-5597(97)96107-4 → PubMed 9186240 →

Electrodes placed directly on the brain surface in patients being assessed for epilepsy surgery were used to find where the contingent negative variation (a slow brain wave that builds while waiting to respond to a cue) is generated. Recordings during a warned Go/NoGo tone task were compared with the readiness potential recorded before self-paced finger movements. The slow anticipatory wave came from patches across many cortical areas, and its later part was distributed differently from the movement-related readiness potential.