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Biophysical Linkage between MRI and EEG Coherence in Closed Head Injury

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Check out this Knowledge Base article from StressTherapy Solutions: Biophysical Linkage between MRI and EEG Coherence in Closed Head Injury.

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Study at a glance

Area
TBI & Concussion
Study type
Observational study
Authors
Thatcher RW, Biver C, McAlaster R, Salazar A
Journal
NeuroImage
Year
1998
Protocol
MRI T2 relaxation times and EEG coherence

Key findings

  • T2 relaxation times in gray and white matter correlated significantly with EEG coherence
  • Longer T2 times related to lower short-distance (such as 7 cm) and higher long-distance (such as 28 cm) coherence
  • In patients, gray matter T2 times related most strongly to the delta and theta frequencies
  • Longer T2 times and lower short-distance coherence were associated with reduced cognitive function

DOI 10.1006/nimg.1998.0365 → PubMed 9811550 →

This study linked MRI and EEG measures in people with closed head injury. Researchers measured T2 relaxation times of water protons in cortical gray and white matter alongside EEG coherence in two independent patient groups and a group of healthy controls. Longer T2 times went with lower coherence between nearby electrodes, higher coherence between distant ones, and poorer cognitive function. The authors interpret this as reduced integrity of neural membranes and less efficient short- and long-distance neural synchronization after traumatic brain injury.