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Mirrored Bilateral Slow-Wave Cortical Activity within Local Circuits Revealed by Fast Bihemispheric Voltage-Sensitive Dye Imaging in Anesthetized and Awake Mice

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Check out this Knowledge Base article from StressTherapy Solutions: Mirrored Bilateral Slow-Wave Cortical Activity within Local Circuits Revealed by Fast Bihemispheric Voltage-Sensitive Dye Imaging in Anesthetized and Awake Mice.

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Study at a glance

Area
QEEG, Methods & Mechanisms
Study type
Observational study
Authors
Mohajerani MH, McVea DA, Fingas M, Murphy TH
Journal
The Journal of Neuroscience
Year
2010
Protocol
voltage-sensitive dye imaging in mice

Key findings

  • Spontaneous slow-wave activity was highly synchronized between the two hemispheres
  • Synchrony depended on the corpus callosum, as shown in acallosal I/LnJ mice
  • Oscillations consisted of multiple discrete local peaks spread unevenly across cortex rather than uniform global shifts
  • Local patterns changed over tens of milliseconds yet were faithfully mirrored in both hemispheres

DOI 10.1523/jneurosci.6437-09.2010 → PubMed 20220008 →

Using voltage-sensitive dye (VSD) imaging across both cortical hemispheres in adult mice, anesthetized and quietly awake, researchers asked whether spontaneous slow-wave oscillations sweep the cortex uniformly or reflect local circuit activity. The oscillations were tightly synchronized between hemispheres, and mice lacking a corpus callosum showed this synchrony depended on it. Each oscillation was built from complex, uneven local patterns that were mirrored in both hemispheres. The authors conclude that global spontaneous rhythms contain orchestrated processing within local cortical circuits.