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Non-linear EEG analyses predict non-response to rTMS treatment in major depressive disorder

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Check out this Knowledge Base article from StressTherapy Solutions: Non-linear EEG analyses predict non-response to rTMS treatment in major depressive disorder.

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Study at a glance

Area
Depression & Mood
Study type
Observational study
Authors
Arns M, Cerquera A, Gutiérrez RM, Hasselman F, Freund JA
Journal
Clinical Neurophysiology
Year
2014
Participants
107 (90 + 17 controls)
Population
Adults
Protocol
Non-linear EEG measures before rTMS
Sessions
21 rTMS sessions on average

Key findings

  • A change in EEG complexity predicted non-response to rTMS

DOI 10.1016/j.clinph.2013.11.022 → PubMed 24360132 →

Ninety people with major depression were treated with rTMS and psychotherapy, and their baseline EEG was analyzed with non-linear complexity measures in the alpha band. People who did not respond showed falling EEG complexity from the first to the second minute of recording, while responders and healthy controls showed a rise, making this a possible early marker of non-response.