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Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging

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Check out this Knowledge Base article from StressTherapy Solutions: Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging.

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Study at a glance

Area
Ageing, Memory & Cognition
Study type
Observational study
Authors
Prichep LS, John ER, Ferris SH, Rausch L, Fang Z, Cancro R, Torossian C, Reisberg B
Journal
Neurobiology of Aging
Year
2006
Participants
44 older adults with subjective complaints only
Population
Older adults
Protocol
baseline resting QEEG with 7-9 year follow-up

Key findings

  • Baseline QEEG of later decliners differed from non-decliners (p < 0.0001, MANOVA)
  • Decliners showed increased theta power, slower mean frequency and changed regional covariance, especially on the right
  • Baseline QEEG features predicted future decline with an R2 of 0.93
  • Overall predictive accuracy was 90%

DOI 10.1016/j.neurobiolaging.2005.07.021 → PubMed 16213630 →

A long-term follow-up study asking whether QEEG can predict which older adults with only subjective memory complaints will later decline. Forty-four elderly people with no objective cognitive deficit had clinical, neurocognitive and QEEG exams at baseline and were reassessed 7 to 9 years later. Baseline QEEG differed clearly between those who later declined and those who did not, with more theta power, slower mean frequency and altered relations between regions, mainly over the right hemisphere. The authors conclude baseline QEEG is a highly sensitive and specific predictor of future decline in this group.