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Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay

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Check out this Knowledge Base article from StressTherapy Solutions: Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay.

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Study at a glance

Area
Other research
Study type
Controlled study
Authors
Colak D, Ji SJ, Porse BT, Jaffrey SR
Journal
Cell
Year
2013
Protocol
molecular and cellular study of axon guidance

Key findings

  • Robo3.2 is synthesized locally within commissural axons, triggered by floor-plate signals as axons cross the midline
  • NMD degrades Robo3.2 transcripts in axons that encounter the floor plate
  • Neurons deficient in NMD proteins showed aberrant trajectories after crossing the midline
  • Local translation in axons is regulated by mRNA stability, with NMD acting locally

DOI 10.1016/j.cell.2013.04.056 → PubMed 23746841 →

A cell biology study of how growing nerve fibers (axons) steer toward their targets. The researchers found that Robo3.2, a receptor for Slit guidance signals, is made locally inside axons of commissural neurons as they cross the spinal cord midline, and that nonsense-mediated mRNA decay (NMD) then breaks down its messenger RNA. Neurons lacking NMD proteins took abnormal paths after crossing the midline. The authors conclude that local mRNA stability helps regulate axon pathfinding.