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Toward a better understanding of the pathophysiology of OCD SSRI responders: QEEG source localization

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Check out this Knowledge Base article from StressTherapy Solutions: Toward a better understanding of the pathophysiology of OCD SSRI responders: QEEG source localization.

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Study at a glance

Area
Anxiety & Stress
Study type
Observational study
Authors
Bolwig TG, Hansen ES, Hansen A, Merkin H, Prichep LS
Journal
Acta Psychiatrica Scandinavica
Year
2007
Population
Adults
Protocol
QEEG source localization (VARETA)

Key findings

  • Excess alpha traced to OCD-related circuits
  • It decreased with successful paroxetine treatment

DOI 10.1111/j.1600-0447.2006.00889.x → PubMed 17302624 →

Resting EEG source localization in people with obsessive-compulsive disorder showed excess alpha arising from the striatum and the orbitofrontal and temporo-frontal regions. This excess fell in patients who responded to the antidepressant paroxetine, matching earlier brain-imaging findings on the circuits involved in OCD.