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Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment

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Check out this Knowledge Base article from StressTherapy Solutions: Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment.

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Study at a glance

Area
Ageing, Memory & Cognition
Study type
Observational study
Authors
Koenig T, Prichep L, Dierks T, Hubl D, Wahlund LO, John ER, Jelic V
Journal
Neurobiology of Aging
Year
2005
Participants
419 (264 New York, 155 Stockholm)
Population
Older adults
Protocol
resting EEG, Global Field Synchronization

Key findings

  • Patients had lower GFS in the alpha, beta and gamma bands
  • Patients had higher GFS in the delta band
  • Findings support the hypothesized functional disconnection of brain networks in MCI and Alzheimer's disease
  • GFS condenses global phase-locked activity into a single number per frequency, independent of recording reference

DOI 10.1016/j.neurobiolaging.2004.03.008 → PubMed 15582746 →

This study tested the idea that mild cognitive impairment (MCI) and Alzheimer's disease involve a breakdown in communication between brain networks. Resting EEG from databases in New York (264 subjects) and Stockholm (155 subjects), including healthy controls and patients at various stages of decline, was analyzed with Global Field Synchronization (GFS), a reference-independent measure of how much activity is phase-locked across the scalp at each frequency. Patients showed the pattern the authors expected from a disconnection syndrome.