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A stable pattern of EEG spectral coherence distinguishes children with autism from neuro-typical controls – a large case control study

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Check out this Knowledge Base article from StressTherapy Solutions: A stable pattern of EEG spectral coherence distinguishes children with autism from neuro-typical controls – a large case control study.

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Study at a glance

Area
Autism
Study type
Observational study
Authors
Duffy FH, Als H
Journal
BMC Medicine
Year
2012
Participants
1,304 (463 with ASD, 571 controls; 984 aged 2-12 in the main analysis)
Population
Children
Protocol
EEG spectral coherence, principal components and discriminant analysis

Key findings

  • Coherence factors classified children with roughly 86-99% accuracy across age bands
  • Autism groups showed reduced short-distance coherence and both reduced and increased long-distance coherence
  • Suggests a stable, measurable EEG connectivity pattern in autism

DOI 10.1186/1741-7015-10-64 → PubMed 22730909 →

A large EEG study of more than a thousand children, asking whether patterns of coherence (how closely the EEG at different sites moves together) can tell children with autism apart from typically developing children. After careful artifact handling, a set of coherence factors separated the groups with high accuracy at every age band studied, suggesting a stable EEG connectivity signature of autism.