sLORETA and fMRI Detection of Medial Prefrontal Default Network Anomalies in Adult ADHD
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Study at a glance
- Area
- ADHD & Attention
- Study type
- Observational study
- Authors
- Cannon R, Kerson C, Hampshire A
- Journal
- Journal of Neurotherapy
- Year
- 2011
- Participants
- 13 adults (6 with ADHD, 7 without)
- Population
- Adults
- Protocol
- 19-channel EEG with sLORETA and fMRI (eyes open, eyes closed, Stroop task)
Key findings
- sLORETA and fMRI both identified a region in medial Brodmann area 10 of the default network
- Frontal group differences extended to medial Brodmann area 32, weighted toward the left prefrontal cortex
- ADHD participants had less sLORETA current source density at Brodmann area 10 than controls
- Authors note sLORETA can indicate the direction of a difference, which fMRI alone cannot
A study comparing two ways of imaging the default mode network in adults with and without ADHD: EEG source localization with standardized low-resolution electromagnetic tomography (sLORETA), and fMRI. Six adults with ADHD and seven without had 19-channel EEG and, separately, fMRI with eyes open, eyes closed and during the Stroop task. Both methods pointed to medial Brodmann area 10, where ADHD participants showed lower sLORETA current density. The authors conclude sLORETA localizes default network sources adequately compared with fMRI and also shows the direction of differences.