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Standardized low-resolution electromagnetic tomography in obsessive–compulsive disorder—A replication study

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Check out this Knowledge Base article from StressTherapy Solutions: Standardized low-resolution electromagnetic tomography in obsessive–compulsive disorder—A replication study.

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Study at a glance

Area
Anxiety & Stress
Study type
Observational study
Authors
Kopřivová J, Horáček J, Raszka M, Brunovský M, Praško J
Journal
Neuroscience Letters
Year
2013
Participants
50 OCD patients (8 drug-free, 42 on SSRIs) and 50 healthy controls
Protocol
resting EEG with sLORETA source localization

Key findings

  • OCD patients had excess 2 and 3 Hz power in the cingulate gyrus, peaking in Brodmann area 24
  • The slow activity was unrelated to symptom severity or illness duration
  • Delta power in the right orbitofrontal cortex correlated positively with age of OCD onset
  • Replicates the team's earlier finding of low-frequency excess in the cingulate gyrus in OCD

DOI 10.1016/j.neulet.2013.05.015 → PubMed 23701862 →

A replication study of EEG sources in obsessive-compulsive disorder (OCD), using a new sample of 50 patients (most taking selective serotonin reuptake inhibitor, or SSRI, antidepressants) and 50 healthy controls. Resting EEG was analyzed in 8 frequency bands and in 1 Hz steps with standardized low-resolution electromagnetic tomography (sLORETA). Patients showed excess slow (2 to 3 Hz) activity in the cingulate gyrus, confirming the group's earlier finding. The authors propose that this delta activity may reflect a repeated need for reinforcement that drives compulsive behavior.