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Combined fMRI and LORETA study of illusory contour perception in schizophrenia

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Check out this Knowledge Base article from StressTherapy Solutions: Combined fMRI and LORETA study of illusory contour perception in schizophrenia.

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Study at a glance

Area
Other research
Study type
Observational study
Authors
Ikeda C, Kirino E
Journal
International Congress Series
Year
2004
Protocol
fMRI and ERP-based LORETA during illusory contour viewing

Key findings

  • Controls showed stronger illusory-contour activation in extrastriate cortex, including area V2
  • Patients showed more activation in the right anterior cingulate and both middle frontal gyri
  • LORETA showed greater current density in the left insula in patients
  • Authors propose weak early perceptual integration in schizophrenia increases prefrontal demands

DOI 10.1016/j.ics.2004.04.101 →

People with schizophrenia and healthy controls viewed illusory contours (the Kanizsa square) and control shapes during fMRI and event-related potential (ERP) recordings, with brain sources estimated using low resolution brain electromagnetic tomography (LORETA). Controls showed stronger responses in visual areas beyond the primary cortex, while patients showed more activity in frontal and insular regions. The authors suggest patients may integrate visual information poorly at early stages, placing extra load on higher-level frontal processing.